Reciprocal interactions between the host circadian clock and the microbiota are evidenced by recent literature. Interestingly, dysregulation of either the circadian clock or microbiota is associated with common human pathologies such as obesity, type 2 diabetes, or neurological disorders. However, it is unclear to what extent a perturbation of pathways regulated by both the circadian clock and microbiota is involved in the development of these disorders. It is speculated that these perturbations are associated with impaired growth hormone (GH) secretion and (...) sexual development. The GH axis is a broadly neglected pathway and could be the main converging point for the interaction of both circadian clock and microbiota. Here, the links between the circadian clock and microbiota are reviewed. Finally, the effects of chronodisruption and dysbiosis on physiology and pathology are discussed and it is speculated whether a common deregulation of the GH pathway could mediates those effects. (shrink)

This issue is dedicated to consciousness in medieval and early modern philosophy of mind. It aims to shed new light on the continuities and innovations during the transition from medieval to early modern philosophy of mind. The four papers, by Sonja Schierbaum, Daniel Schmal, Oliver Istvan Toth, and Philipp N. Müller, focus on consciousness and, more specifically, on one of its less frequently considered aspects: memory.

Book reviewed in this article: The Concept of Moral Consensus: The Case of Technological Interventions into Human Reproduction. Edited by Kurt Bayertz. Deciding Together: Bioethics and Moral Consensus. By Jonathan D. Moreno.

Written by a nurse and a philosopher, Ethics in Nursing blends the concrete detail of recurring problems in nursing practice with the perspectives, methods, and resources of philosophical ethics. It stresses the aspects of the nurses role and relations with others -- physicians, patients, administrators, other nurses -- that give ethical problems in nursing their special focus. Among the issues addressed are deception, parentalism, confidentiality, conscientious refusal, nurse autonomy, compromise, and personal responsibility for institutional and public policy. The third edition (...) has been enlarged with new cases and case discussions related to AIDS and an additional chapter on the expanding scope of nursing ethics as it addresses issues related to scarce resources, cost containment, justice, and the possibilities of health care rationing. (shrink)

The modal -calculus extends basic modal logic with second-order quantification in terms of arbitrarily nested fixpoint operators. Its satisfiability problem is EXPTIME-complete. Decision procedures for the modal -calculus are not easy to obtain though since the arbitrary nesting of fixpoint constructs requires some combinatorial arguments for showing the well-foundedness of least fixpoint unfoldings. The tableau-based decision procedures so far also make assumptions on the unfoldings of fixpoint formulas, e.g., explicitly require formulas to be in guarded normal form. In this paper (...) we present a tableau calculus for deciding satisfiability of arbitrary, i.e., not necessarily guarded -calculus formulas. It is based on a new unfolding rule for greatest fixpoint formulas which allows unguarded formulas to be handled without an explicit transformation into guarded form, thus avoiding a exponential blow-up in formula size. We prove soundness and completeness of the calculus, and compare it empirically to using guarded transformation instead. The new unfolding rule can also be used to handle nested star operators in PDL formulas correctly. (shrink)

The chapters in this section of the volume reveal the striking variety of human numerical cognition. The section comprises four chapters that focus on different aspects of the representation of numerical knowledge, as well as three chapters that examine the several cognitive processes involved in the manipulation of numbers during simple mental arithmetic. They show how chronometric analyses, in combination with clever experimental designs, can reveal the cognitive processes and representations underlying this impressive collection of cognitive skills. Our goal in (...) this overview chapter is to highlight common themes that connect these contributions. In particular, we suggest links between the present contributions, all of which are firmly grounded in the traditional information-processing approach to the human mind, and the more recently emerged embodied cognition perspective, according to which all knowledge representations remain associated with those sensory and motor features that were activated during acquisition of that knowledge. (shrink)

In this paper we discuss ‘sustainable management’ which is being advocated by some in the business community. It may be that a professed commitment to sustainable development is merely a way for contemporary businesses to continue with ‘business as usual’ behind its façade. We believe that if business practices are to change, then education must change to allow students to live the ‘good’ lives promoted both by early philosophers and now by those professing the merits of sustainable development. The sustainable (...) development paradigm, if adopted fully, may result in the best of business decisions being made; it may provide humankind with a way to avoid the self-destruction which has been threatening throughout the 20th Century. Sustainable management requires business decision makers to consider how their decisions will affect the social and natural environments as well as their organisations’ profitability. It encourages a moral approach to business decision making and requires managers to recognise that genuinely long-term decision criteria will ultimately benefit their businesses, their societies, the natural environment and humankind. Although sustainable management is promoted as a ‘new’ paradigm, we argue that its principles should have been promoted through our educational systems for many centuries; they have not been. (shrink)

Recent discussions of ontology have shown an interest in the relation between logic, language and ontology. Quine, for example, has shown how sentences translated into canonical form determine ontological commitment in terms of the values over which bound variables range, while Strawson has maintained that conditions inherent to language determine a system of ontological concepts. But in these discussions the role linguistics might have in the construction of ontological schemes is seldom seriously considered. Except for Benjamin Lee Whorf’s examination (...) through the use of descriptive linguistic techniques of the relation between ontological schemes and the structure of languages, little has been done to apply the results of linguistic research to questions of ontology. In the past this could be attributed to the absence in structural linguistics of significant generalizations about language above the morphophonemic level. This situation has altered with the development of transformational linguistic theory. That theory contains an extensive set of generalizations about the form and content of any natural language. (shrink)

Der Begriff der Autorität verortet sich im 20. Jahrhundert in einer komplexen Matrix zwischen zeitgeschichtlichem Problembewusstsein, »konservativem« Denken und politischer Theoriebildung. Drei Perspektiven kennzeichnen die Rede von Autorität im 20. Jahrhundert: erstens die vermeintliche Krise einer vormals fraglosen Gültigkeit, zweitens der Versuch genealogischer Rückversicherung durch Versatzstücke der Tradition und drittens die Behauptung, Autorität könne als Grundbegriff politischer Theoriebildung und insbesondere demokratischer Ordnungen dienen. Der Sammelband analysiert das Konzept der Autorität entsprechend entlang der drei Dimensionen der Krise, der Konstruktion und der (...) Konjunktur. Der Band arbeitet dabei interdisziplinär: Vereint werden historische, literaturwissenschaftliche und philosophische Ansätze. (shrink)

Moral deliberation involves a constant interplay among specific judgments, general moral values and principles, and background beliefs about the world. We may also construct broad moral theories to explain how our judgments and general commitments hang together, but there is little hope of settling on any one comprehensive moral theory.

Various theories on personal goal striving rely on the assumption that failure raises doubts about the goal. Yet, empirical evidence for an association between objective failure experiences and doubts about personal long-term goals is still missing. In a longitudinal field study, applicants for a job as a police trainee (n = 172, Mage = 25.15, 55 females and 117 males) were accompanied across three measurement times over a period of five months. We investigated the effects of failure and initial expectation (...) of success (in the standardized selection process) on doubts regarding the superordinate goal of becoming a police officer. As hypothesized, both failure and low initial expectation of success as well as their interaction led to increased goal-related doubts over time. The findings provide first empirical evidence for the role of failure in the emergence of goal-related doubts in personal long-term goals and, therefore, the disengagement process as it is hypothesized in various theories on goal striving and life-span development. (shrink)

One finds throughout the history of philosophy repeated though apparently unsuccessful attempts to decide upon the nature or essence of language. This is not a trivial problem. When philosophers themselves have tried to resolve it they seem inevitably to postulate some nonovert level of linguistic form which is more basic to language than its overt grammatical forms. Now linguists have become involved in making similar claims. This is in large measure due to Noam Chomsky’s revolutionary work in transformational generative grammar, (...) research which has lead to a new conception of the goals and nature of linguistic theory. Whatever might be the ultimate fate of Chomsky’s own proposals concerning the nature of language, his insistence on descriptive precision and on theoretically sophisticated models in linguistics will remain paradigmatic. What is in fact most revolutionary about transformational linguistics is not the construction of precise and detailed grammars per se, but the parallel claim that there exist underlying realities of language which to a large extent dictate its overt form and content. For Chomsky these realities are part of the deep structure of language. Although other linguists do not share his view that there is an exclusively syntactically based deep structure, transformationalists generally do agree that there is some linguistic level underlying surface structure which accounts for it. Disagreement exists over the nature of this underlying reality, and it is on this issue that linguistics has a significant point of contact with philosophy. (shrink)

Critically examining what most people take for granted is central to philosophical inquiry. Philosophers who accept positions on policy making commissions, tasks forces, or committees cannot, however, play the same uncompromisingly critical role in this capacity as they do in the classroom or in their personal research or writing. Still, philosophers have much to contribute to such bodies, and they can do so without compromising their integrity or betraying themselves as philosophers. Keywords: compromise, critical reflection, embryo research, integrity, organ transplantation, (...) policy development, Warnock Committee CiteULike Connotea Del.icio.us What's this? (shrink)

En este texto se recoge la experiencia y el estudio realizado en el Grado de Educación Infantil del Centro Universitario Cardenal Cisneros (Madrid), ante la necesidad de mostrar a los estudiantes del 2º curso, matriculados en la asignatura “La Innovación Educativa” otra forma de aprender y enseñar, basándose en su propia experiencia. Pero para poder valorar esta experiencia, era necesario encontrar un modelo a seguir y desde el que recoger información, indagar sobre lo que ocurría en la propia aula y (...) ofrecer un proceso formativo e investigador flexible. Para ello se utilizó la metodología de la investigación-acción. (shrink)

The interdisciplinary field of cognitive science brings together elements of cognitive psychology, mathematics, perception, and linguistics. Focusing on the main areas of exploration in this field today, Cognitive Science presents comprehensive overviews of research findings and discusses new cross-over areas of interest. Contributors represent the most senior and well-established names in the field. This volume serves as a high-level introduction, with sufficient breadth to be a graduate-level text, and enough depth to be a valued reference source to researchers.

Protein turnover (PT) has been formally defined only in equilibrium conditions, which is ill‐suited to quantify PT during dynamic processes that occur during embryogenesis or (extra) cellular signaling. In this Hypothesis, we propose a definition of PT in an out‐of‐equilibrium regime that allows the quantification of PT in virtually any biological context. We propose a simple mathematical and conceptual framework applicable to a broad range of available data, such as RNA sequencing coupled with pulsed‐SILAC datasets. We apply our framework to (...) a published dataset and show that stimulation of mouse dendritic cells with LPS leads to a proteome‐wide change in PT. This is the first quantification of PT out‐of‐equilibrium, paving the way for the analysis of biological systems in other contexts. (shrink)

Moral dilemmas and ethical inquiry -- Unavoidable topics in ethical theory -- Nurses and clients -- Recurring ethical issues in interprofessional relationships -- Ethical dilemmas among nurses -- Personal responsibility for institutional and public policy -- Cost containment, justice, and rationing.

Martin Benjamin bridges the gap between academic philosophy and the questions of educated nonspecialists.

Discusses how to distinguish metaphysics from ideology.